The Dallas Observer has collected a few clips from movies where the music has been replaced by Cee-Lo's Fuck You. The Dirty Dancing one is probably the best:
I wonder how the slow-dance scene at the end of Rushmore would work. Or the Enchantment Under the Sea Dance in Back to the Future. Audio NSFW. (via @erikmal)
Great song by Cee-Lo, who you may know as one half of Gnarls Barkley.
NSFW in both the visual and audio departments for extensive use of the phrase "fuck you".
I love Anil's comment that the video is "a little bit Tobias, and a little bit Sasha". And indeed the typeface in the video is Champion Gothic, designed by Tobias Frere-Jones' partner, Jonathan Hoefler.