Over the holidays, Mike Monteiro discovered there was a Nacho Libre game for the Nintendo DS. Thinking that an arbitrary choice for a movie tie-in game, he started the DS Tie-In Games I Wanna Play group on Flickr to showcase other possible odd media tie-ins for the DS. Some of my favorite submissions so far include: The Passion of the Christ, Birth of a Nation, Empire, Remains of the Day, My Dinner with Andre (Bon Mot controller sold separately), Super Mario Bros, Learning GNU Emacs, Requiem for a Dream, The Cremaster Cycle, and Getting Things Done.
Here's a couple of ones that I've done: Dancer in the Dark and The New Yorker Draw Your Own Cover Electronic Entertainment (with noncompulsory coöperative mode), pictured below.
If you join the group, there's a Photoshop kit you can download to join in the fun.